Themes

Research

The physics of living, swimming matter — how cells navigate flow, geometry, and chemistry, and how we engineer environments to study them.

Cell Newton cover
01

Bacterial upstream invasion

Flagellated bacteria swim against ambient flow and invade microstructured devices through hydrodynamic boundary interactions. We resolve the geometry-dependent transport that funnels swimmers into confined channels.

PNAS 2024 rheotaxis figure
02

Complex fluids & rheotaxis

Polymeric, viscoelastic, and macromolecular fluids dramatically enhance bacterial upstream swimming. We disentangle the rheological and hydrodynamic contributions to collective rheotactic behavior.

PNAS 2025 biofilm dispersal figure
03

Nitric oxide & biofilm dispersal

NO rapidly switches V. cholerae from sessile biofilm to a hyper-motile state, accelerating dispersal — quantified with microfluidic flow assays and high-speed tracking.

Topological separation lattice device
04

Topological separation of active matter

Periodic microfluidic lattices act as topological filters for bacterial active matter, separating swimmers by trajectory winding and persistence length.

Multiflagellarity bacteria
05

Multiflagellarity & morphology

Cell shape and flagellar number jointly govern upstream invasion success. We map a morphology phase diagram for bacterial transport in flow.

AMR diagnostic chip
06

Antimicrobial resistance diagnostics

Microfluidic AMR phenotyping for urinary tract infections — fast, single-cell readouts of resistance in clinically relevant strains.